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KMID : 0364020110440020165
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Korean Journal of Thoracic and Cardiovascular Surgery
2011 Volume.44 No. 2 p.165 ~ p.168
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Complete Resection of Pulmonary Metastatic Melanoma
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Kim Jae-Jun
Park Jae-Kil
Wang Young-Pil
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Abstract
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Background: The prognosis of melanoma metastasized to other organs is very poor. There have been many studies on metastatic melanoma in Western society, but there have been few studies done in Korea because of the small number of cases.
Materials and Methods: A retrospective review of 7 patients who underwent complete resection of pulmonary metastases from melanoma from January 2005 to December 2009 was performed. When the primary lesion was controlled or simultaneously controllable and no other metastatic lesion was found, pulmonary resections were performed. We analyzed the clinical prognoses after the initial melanoma diagnosis.
Results: Of the seven patients, one was male and six were female. The mean age was 58.2 years (range 45∼71). Six patients had a single pulmonary lesion and one patient had three lesions confined to the same lobe. The mean disease-free interval was 43.5 months (0∼146 months). Before pulmonary resection, 4 patients had received systemic therapy. After pulmonary resection, 6 patients received systemic therapy. Complete resection was confirmed histologically. The metastasectomy was performed by wedge resection (6 patients) or lobectomy (1 patient). There were no mortalities or complications. After pulmonary resection, 1 patient had recurrent multiple lesions in the lung and 4 patients had metastases to other organs. The organs were the liver, brain, pleura, and lymph nodes. The mean observation time was 31.6 months and 3 patients died during observation. The mean survival was 27.7 months (14∼60 months) and the 1-year and 3-year survival rates were 100% and 42%, respectively.
Conclusion: When patients were selected carefully, the complete resection of pulmonary metastatic lesions was considered a major therapeutic tool.
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KEYWORD
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Metastasectomy, Melanoma, Prognosis
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